~ We are using next generation sequencing strategies to map the epigenome during cell cycle.

~ We are identifying chromatin and non-coding RNAs that are regulating cell cycle progression.

Recent Press Release (click here)

~  What cellular cues or exposures drive ecDNA amplification?

~  How does signaling and epigenetic-related pathways control amplifications?

~  What genomic and epigenomic features control extrachromosomal DNA amplification?

~  Can we extend our discoveries into the clinic to tackle drug resistant & heterogenous tumors?

~  How does epigenetic control of replication timing and rereplication contribute to amplification?

Newest paper- click here

Epigenetic Mechanisms Impacting Cancer Therapy

Epigenetic Mechanisms Driving Copy Gain, Amplifications and Drug Resistance

Relevant Manuscripts

Recent Press Release (click here)

Recent Press Release (click here)

Epigenetic Mechanisms Regulating Cell Cycle Progression

~  What chromatin factors either enhance or suppress therapy?

(e.g., immune checkpoint & chemotherapy)

~  What impact do polymorphisms and somatic mutations have on epigenetic regulator function and contribution to cancer.

Relevant Manuscripts

Relevant Manuscripts

Newest paper- click here

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