~ What chromatin factors either enhance or suppress therapy?
(e.g., immune checkpoint & chemotherapy)
~ What impact do polymorphisms and somatic mutations have on epigenetic regulator function and contribution to cancer.
Epigenetic Mechanisms Impacting Cancer Therapy
Epigenetic Mechanisms Driving Copy Gain, Amplifications and Drug Resistance
Epigenetic Mechanisms Regulating Cell Cycle Progression
~ We are using next generation sequencing strategies to map the epigenome during cell cycle.
~ We are identifying chromatin and non-coding RNAs that are regulating cell cycle progression.
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~ What cellular cues or exposures drive ecDNA amplification?
~ How does signaling and epigenetic-related pathways control amplifications?
~ What genomic and epigenomic features control extrachromosomal DNA amplification?
~ Can we extend our discoveries into the clinic to tackle drug resistant & heterogenous tumors?
~ How does epigenetic control of replication timing & rereplication contribute to amplification?