~ What cellular cues or exposures drive ecDNA amplification?
~ How does signaling and epigenetic-related pathways control amplifications?
~ What genomic and epigenomic features control extrachromosomal DNA amplification?
~ Can we extend our discoveries into the clinic to tackle drug resistant & heterogenous tumors?
~ How does epigenetic control of replication timing & rereplication contribute to amplification?
~ What chromatin factors either enhance or suppress therapy?
(e.g., immune checkpoint & chemotherapy)
~ What impact do polymorphisms and somatic mutations have on epigenetic regulator function and contribution to cancer.
Epigenetic Mechanisms Impacting Cancer Therapy
Epigenetic Mechanisms Regulating Cell Cycle Progression
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~ We are using next generation sequencing strategies to map the epigenome during cell cycle.
~ We are identifying chromatin and non-coding RNAs that are regulating cell cycle progression.
Epigenetic Mechanisms Driving Extrachromosomal DNA Amplifications, Rearrangements & Drug Resposnse